4-Isothiocyanato-2-(trifluoromethyl)benzonitrile (CAS No: 143782-23-4) is a key pharmaceutical intermediate used in the synthesis of APIs Enzalutamide. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: Benzonitrile, 4-isothiocyanato-2-(trifluoromethyl)-;, Enzalutamide Impurity N7
CAS No: 143782-23-4
PubChem CID: 11615540
Mol Formula: C9H3F3N2S
Mol Weight: 228.20 g/mol
Used in API: Enzalutamide
IUPAC Name: 4-isothiocyanato-2-(trifluoromethyl)benzonitrile
API Intermediate Description: 4-Isothiocyanato-2-(trifluoromethyl)benzonitrile is a crucial intermediate in the synthesis of Enzalutamide. It reacts with N-methyl-2-fluoro-4-(1,1-dimethyl-cyanomethyl)-aminobenzamide to form the thiohydantoin ring (thioimidazolinone) of Enzalutamide. This compound is typically prepared from 4-amino-2-(trifluoromethyl)benzonitrile using thiophosgene.
