4-(3-((Allyloxy)methyl)phenyl)-2-chloropyrimidine (CAS No: 937273-29-5) is a key pharmaceutical intermediate used in the synthesis of APIs Pacritinib. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: 2-chloro-4-[3-(prop-2-enoxymethyl)phenyl]pyrimidine, 4-[3-(allyloxymethyl)phenyl]-2-chloro-pyrimidine
CAS No: 937273-29-5
PubChem CID: 53363692
Mol Formula: C14H13ClN2O
Mol Weight: 260.72 g/mol
Used in API: Pacritinib
IUPAC Name: 2-chloro-4-[3-(prop-2-enoxymethyl)phenyl]pyrimidine
API Intermediate Description: 4-(3-((Allyloxy)methyl)phenyl)-2-chloropyrimidine is a key intermediate in synthesizing Pacritinib, used in a crucial step where its chloropyrimidine part reacts (often via nucleophilic aromatic substitution or similar coupling) with the aniline fragment (like 3-((allyloxy)methyl)-4-(2-(pyrrolidin-1-yl)ethoxy)aniline) to form the core structure that eventually cyclizes and gets modified to yield the final drug. It provides the substituted phenyl-pyrimidine scaffold, with the allyloxy group later being involved in the macrocycle formation or removed/modified in subsequent steps to build the complex structure of Pacritinib.
