4-(1,2,4-Triazol-1-ylmethyl)benzonitrile (CAS No: 112809-25-3) is a key pharmaceutical intermediate used in the synthesis of APIs Letrozole. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: 1-(4-cyanobenzyl)-1,2,4-triazole;, Letrozole Impurity 4
CAS No: 112809-25-3
PubChem CID: 7537616
Mol Formula: C10H8N4
Mol Weight: 184.20 g/mol
Used in API: Letrozole
IUPAC Name: 4-(1,2,4-triazol-1-ylmethyl)benzonitrile
API Intermediate Description: 4-(1,2,4-Triazol-1-ylmethyl)benzonitrile is a crucial intermediate in the synthesis of Letrozole, acting as the core benzonitrile-triazole fragment that reacts with 4-fluorobenzonitrile (or related precursors) using a strong base (like potassium tert-butoxide) to form the final Letrozole molecule, which is an aromatase inhibitor for breast cancer treatment. This two-step process involves first creating the intermediate from 4-(bromomethyl)benzonitrile and 1,2,4-triazole, then coupling it to complete the Letrozole structure.
