3-Hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one, (2S,3S)- (CAS No: 42399-49-5) is a key pharmaceutical intermediate used in the synthesis of APIs Diltiazem. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: (2S,3s)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5h)-one, 1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-, (2S-cis)-
CAS No: 42399-49-5
PubChem CID: 2733673
Mol Formula: C16H15NO3S
Mol Weight: 301.4 g/mol
Used in API: Diltiazem
IUPAC Name: (2S,3S)-3-hydroxy-2-(4-methoxyphenyl)-3,5-dihydro-2H-1,5-benzothiazepin-4-one
API Intermediate Description: (2S,3S)-3-Hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one is a key chiral intermediate in the synthesis of diltiazem, a calcium channel blocker. Its stereochemistry ((2S,3S) configuration) is crucial because it leads to the biologically active form of the drug. In the synthesis, this compound undergoes acetylation of the hydroxyl group followed by side-chain introduction (typically via esterification with a dimethylaminoethyl group), ultimately forming diltiazem. The controlled formation and preservation of its stereocenters ensure the desired pharmacological activity and selectivity of the final product.
