2,2-dimethyl-N-[2-methyl-2-(4-nitro-1H-imidazol-1-yl)propyl]propan-1-amine (CAS No: 865774-15-8) is a key pharmaceutical intermediate used in the synthesis of APIs Nirogacestat. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: 1H-Imidazole-1-ethanamine, N-(2,2-dimethylpropyl)-|A,|A-dimethyl-4-nitro-, 2-methyl-N-neopentyl-2-(4-nitro-1H-imidazol-1-yl)propan-1-amine
CAS No: 865774-15-8
PubChem CID: 67164086
Mol Formula: C12H22N4O2
Mol Weight: 254.33 g/mol
Used in API: Nirogacestat
IUPAC Name: 2,2-dimethyl-N-[2-methyl-2-(4-nitroimidazol-1-yl)propyl]propan-1-amine
API Intermediate Description: The compound 2,2-dimethyl-N-[2-methyl-2-(4-nitro-1H-imidazol-1-yl)propyl]propan-1-amine (or its N-nitroso derivative) serves as a crucial building block or intermediate in the synthesis of Nirogacestat, a drug for desmoid tumors, likely forming part of the imidazole-containing core structure or its precursor in patented synthetic routes. Specifically, it provides the unique nitroimidazole-substituted aminopropyl fragment, which is incorporated into the final complex molecule of Nirogacestat.
![2,2-dimethyl-N-[2-methyl-2-(4-nitro-1H-imidazol-1-yl)propyl]propan-1-amine](https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?cid=67164086&t=l)
