2-Bromo-5-methylbenzoic acid (CAS No: 6967-82-4) is a key pharmaceutical intermediate used in the synthesis of APIs Filorexant. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: Benzoic acid, 2-bromo-5-methyl-, Fluralaner Impurity 52
CAS No: 6967-82-4
PubChem CID: 228080
Mol Formula: C8H7BrO2
Mol Weight: 215.04 g/mol
Used in API: Filorexant
IUPAC Name: 2-bromo-5-methylbenzoic acid
API Intermediate Description: 2‑Bromo‑5‑methylbenzoic acid is used in the synthesis of Filorexant (MK‑6096), a dual orexin receptor antagonist that was developed for the treatment of insomnia. In reported synthetic methodology, 2‑bromo‑5‑methylbenzoic acid is coupled with a pyrimidine derivative (such as 2‑chloropyrimidine) using palladium‑catalyzed cross‑coupling (e.g., Negishi coupling) to form 5‑methyl‑2‑(pyrimidin‑2‑yl)benzoic acid, which is an important molecular fragment incorporated into the Filorexant API’s structure.
