1-(Diphenylmethyl)azetidin-3-ol (CAS No: 18621-17-5) is a key pharmaceutical intermediate used in the synthesis of APIs Azelnidipine. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: 1-Benzhydrylazetidin-3-ol, 1-(Diphenylmethyl)-3-hydroxyazetidine
CAS No: 18621-17-5
PubChem CID: 330448
Mol Formula: C16H17NO
Mol Weight: 239.31 g/mol
Used in API: Azelnidipine
IUPAC Name: 1-benzhydrylazetidin-3-ol
API Intermediate Description: 1-(Diphenylmethyl)azetidin-3-ol is used as a key synthetic intermediate in the preparation of azelnidipine, where it serves as a protected azetidine building block that enables controlled introduction of the azetidine moiety into the final drug molecule. The diphenylmethyl group protects the azetidine nitrogen during subsequent transformations, while the 3-hydroxy functionality provides a versatile site for derivatization, such as ester or ether formation, allowing efficient coupling with the dihydropyridine framework. This intermediate is important for achieving the desired substitution pattern, stability, and pharmacological profile of azelnidipine, contributing to its long-acting calcium channel–blocking activity.
