1-C-(4-Chloro-3-((4-ethoxyphenyl)methyl)phenyl)-I+–D-glucopyranose (CAS No: 960404-86-8) is a key pharmaceutical intermediate used in the synthesis of APIs Dapagliflozin. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: Dapagliflozin impurity, Dapagliflozin hydroxy impurity
CAS No: 960404-86-8
PubChem CID: 59648701
Mol Formula: C21H25ClO7
Mol Weight: 424.9 g/mol
Used in API: Dapagliflozin
IUPAC Name: (2S,3R,4S,5S,6R)-2-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-2,3,4,5-tetrol
API Intermediate Description: 1-C-(4-Chloro-3-((4-ethoxyphenyl)methyl)phenyl)-1-deoxy-β-D-glucopyranose is an advanced chiral intermediate used in the manufacturing of Dapagliflozin, an SGLT2 inhibitor for the treatment of type-2 diabetes. This intermediate contains the essential C-aryl-glucoside linkage, which is the defining structural feature of Dapagliflozin. By providing the correct stereochemistry and pre-assembled aryl–glucose framework, it enables efficient downstream transformations to obtain the final API. Its use helps ensure high purity, structural accuracy, and process efficiency in the production of Dapagliflozin, making it a critical building block in the drug’s industrial synthesis.
