1-[(2,6-Difluorophenyl)methyl]-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-6-(4-nitrophenyl)thieno[2,3-d]pyrimidine-2,4-dione (CAS No: 1589503-96-7) is a key pharmaceutical intermediate used in the synthesis of APIs Relugolix. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: 1-(2,6-difluorobenzyl)-5-dimethylaminomethyl-3-(6-methoxypyridazin-3-yl)-6-(4-nitrophenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
CAS No: 1589503-96-7
PubChem CID: 73505508
Mol Formula: C27H22F2N6O5S
Mol Weight: 580.6 g/mol
Used in API: Relugolix
IUPAC Name: 1-[(2,6-difluorophenyl)methyl]-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-6-(4-nitrophenyl)thieno[2,3-d]pyrimidine-2,4-dione
API Intermediate Description: The compound 1-[(2,6-Difluorophenyl)methyl]-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-6-(4-nitrophenyl)thieno[2,3-d]pyrimidine-2,4-dione is a precursor or intermediate used in the synthesis of Relugolix, a GnRH antagonist, where the nitro group on the phenyl ring is typically modified (e.g., reduced to an amine, then reacted to form a urea) to form the final active drug. It's a key building block in creating the complex thienopyrimidine structure of Relugolix.
![1-[(2,6-Difluorophenyl)methyl]-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-6-(4-nitrophenyl)thieno[2,3-d]pyrimidine-2,4-dione](https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?cid=73505508&t=l)
