1-((2-Fluorophenyl)methyl)pyrazolo(3,4-b)pyridine-3-carbonitrile (CAS No: 256376-65-5) is a key pharmaceutical intermediate used in the synthesis of APIs Riociguat. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: 1H-Pyrazolo[3,4-b]pyridine-3-carbonitrile, 1-[(2-fluorophenyl)methyl]-, Riociguat Impurity 8
CAS No: 256376-65-5
PubChem CID: 11402500
Mol Formula: C14H9FN4
Mol Weight: 252.25 g/mol
Used in API: Riociguat
IUPAC Name: 1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridine-3-carbonitrile
API Intermediate Description: 1-((2-Fluorophenyl)methyl)pyrazolo(3,4-b)pyridine-3-carbonitrile (FPPCN) is a crucial intermediate or building block in synthesizing Riociguat (Adempas), a drug for pulmonary hypertension, where it forms the core structure that gets further modified to attach the pyrimidine ring and carbamate group, ultimately creating the active sGC stimulator. This compound provides the essential pyrazolo[4-b]pyridine backbone with the 2-fluorobenzyl substituent, a key feature of Riociguat's structure, according to patents and chemical synthesis descriptions.
