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Alternate Names: Losmapimodum
CAS No: 585543-15-3
PubChem CID: 11552706
Mol Formula: C22H26FN3O2
Mol Weight: 383.5 g/mol
IUPAC Name: 6-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide
API Description: Losmapimod is an investigational p38 kinase inhibitor, primarily used in clinical trials to treat Facioscapulohumeral Muscular Dystrophy (FSHD), aiming to reduce the toxic DUX4 protein, though earlier trials showed mixed results on gene expression but suggested functional benefits. It was initially developed for inflammatory conditions like COPD and cardiovascular issues, but these uses didn't show clinical efficacy, leading to its repurposing for FSHD, where its mechanism targets DUX4-related muscle wasting.
